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Leponex 100 Mg 50 Tablets ingredient Clozapine
Lactose monohydrate, corn starch, povidone, colloidal silica anhydride, magnesium stearate, talc, distilled water
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• If you have previously stopped using LEPONEX due to severe side effects (eg, agranulatosis or heart problems)
• If you have liver, kidney or heart problems,
• If you have uncontrolled seizures,
• If you have a problem with alcohol or drug abuse,
• If you have an acute mental illness caused by alcohol or drugs (eg narcotics)
• If there is inflammation in the heart (myocarditis)
• If you have another severe heart condition,
• If you have severe kidney disease,
• If you have signs of active liver disease such as jaundice (yellowing in the skin and eyes, feeling sick and loss of appetite)
• If you have another severe liver disease,
• If you are experiencing reduced consciousness and severe dizziness,
• If you are experiencing a circulatory collapse that can be seen as a result of a severe shock,
• If you are treated with long-acting depot antipsychotic injections or if you have been before,
• If you have had previous severe constipation, intestinal obstruction, or any other condition that affects your large intestine.
If you think you are allergic to LEPONEX (clozapine), consult your doctor before taking LEPONEX.
Use LEPONEX CAREFULLY in the following situations
• Consult your doctor immediately at the first indication of flu, flu, fever, sore throat or any other infection. LEPONEX can reduce the number of white cells in your blood stream and increase your sensitivity to infection. Your doctor can check your blood cell count and take additional precautions if necessary.
• Consult your doctor if you are experiencing a resting heartbeat which is likely to be accompanied by shortness of breath and swelling of your feet or legs. These effects can occur especially at the beginning of treatment and your doctor may need to take additional precautions.
• Tell your doctor or pharmacist if you have prostate enlargement, convulsions, glaucoma (a condition in which the fluid in the eye is usually very high), diabetes or any other serious medical condition.
• Tell your doctor or pharmacist if you have a stroke or heart condition, or if your family history has a cardiac problem called "prolongation of QT interval".
• Tell your doctor or pharmacist if you have a condition related to dementia.
• LEPONEX can cause infrequent (venous thromboembolic event) that causes blood clots to form in the veins.
• When using LEPONEX, you may experience dizziness or fainting, especially at the beginning of treatment. That's the reason your blood pressure falls.
• Sudden rapid increase in body temperature, if you are experiencing a rigidity (neuroleptic malignant syndrome) that can lead to loss of consciousness in the muscles; you may be experiencing a serious side effect that requires urgent treatment.
• If you are experiencing severe constipation. Your doctor will treat this condition to prevent further complications.
• If you have diabetes (sugar), your doctor can regularly check the sugar level in your blood. LEPONEX may cause changes in blood lipids. LEPONEX may cause weight gain. Your doctor can monitor your weight and blood lipid levels.
• LEPONEX reported heart attacks that could lead to death.
• LEPONEX can cause weight gain and sleepiness in some patients and may cause bed rest for a longer period. This can lead to blood clotting.
Please consult your doctor if these warnings apply to you, even at any time in the past.
Use of LEPONEX with food and drink
You can take LEPONEX tablet with meals or on an empty stomach.
Interaction with alcohol: LEPONEX may increase the effects of alcohol. You should not drink alcohol while taking LEPONEX.
A change in the number of drinks containing caffeine that you quit smoking or drink in a day can affect the levels of LEPONEX in the blood. If you have any such changes in your habits, tell your doctor.
Consult your doctor or pharmacist before using this medication.
If you are pregnant or think you may be pregnant, tell your doctor before using LEPONEX. Your doctor will inform you about the potential risks and benefits of using this medicine during pregnancy.
In some women using antipsychotic drugs, menstrual irregularity or no menstruation is observed. If you are experiencing such a condition, you can start to look again when you change your medicine to LEPONEX. In these cases, you should be sure to use a reliable contraceptive method.
Newly born babies from mothers who used antipsychotic during the last three months of their pregnancy; After birth, there may be an increased risk of rigidity in the arms and legs, tremors, restlessness, muscle stiffness, muscle loosening, drowsiness, respiratory distress and malnutrition.
While some of these cases may improve on their own, some of them may require intensive care unit support or hospitalization.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Consult your doctor or pharmacist before using this medication.
If you are breastfeeding, tell your doctor or pharmacist. The active ingredient of LEPONEX, clozapine, can pass through the mother and affect the baby. You should not breast-feed during LEPONEX treatment.
Vehicle and machine use
LEPONEX can lead to instability, especially at the beginning of treatment. For this reason, you should not use a car or a machine until you have learned a lot and are feeling dizzy.
Important information about some of the auxiliary substances contained in LEPONEX
LEPONEX tablets contain lactose. If your doctor tells you that you are not tolerant to certain sugars (eg lactose), tell your doctor before you start using LEPONEX.
Use with other medicines
Before starting to use LEPONEX, tell your doctor if you are taking another medication or if you have been using it recently. These medicines include prescription medicines or herbal remedies. You may need to change the amount of your medications or use other medications.
LEPONEX should not be used concurrently with medications that suppress bone marrow function and / or reduce the number of blood cells produced by the body. These drugs
• Carbamazepine (a drug used in epilepsy).
Certain antibiotics: sulfonamides such as chloramphenicol, cotrimoxazole.
Certain analgesics: pyrazolone analgesics such as phenylbutazone.
• Penicillamine (a drug used in the treatment of rheumatoid arthritis).
• Cytotoxic agents (drugs used in chemotherapy).
• Long-acting depot injections of antipsychotics (effective in the treatment of psychiatric disorders such as schizophrenia and psychotic depression).
These drugs increase your risk of developing agranulocytosis (deficiency of white blood cells).
Using LEPONEX can change the rate of action of your other drugs or they can change the rate of action of LEPONEX. If you are using any of the following medicines, tell your doctor:
• Drugs used in the treatment of depression such as lithium, fluvoxamine, tricyclic antidepressants, MAO inhibitors, citalopram, paroxetine, fluoxetine and sertraline.
• Other antipsychotics used in the treatment of mental illness (drugs that are effective in the treatment of psychiatric disorders such as schizophrenia and psychotic depression).
• Benzodiazepines and other medicines used in the treatment of anxiety or sleep disorders.
• Narcotics and other drugs that can affect your breathing.
• Medications used to control epilepsy, such as phenytoin and valproic acid.
• Used to treat high or low blood pressure, such as adrenaline and noradrenalin
• Warfarin (a drug used to prevent blood clots).
• Antihistamines (drugs used for allergies such as colds or hay fever).
• Anticholinergic drugs (relieving stomach cramps, contractions and travel illnesses
• Drugs used to treat Parkinson's disease.
• Digoxin (a drug used in the treatment of heart problems).
• Drugs used to treat fast or irregular heartbeat.
• Some medications used in the treatment of stomach ulcers, such as omeprazole or cymetidine.
• Some antibiotic drugs such as erythromycin and rifampicin.
• Fungal infections (such as ketoconazole) or viral infections (such as HIV infections
such as protease inhibitors used in the treatment of certain drugs).
• Atropine (available for some eye drops or cough or cold preparations)
• Adrenaline (a drug used in an emergency).
This list is not complete. Your doctor or pharmacist should take care when using LEPONEX or
it will give you more information about the medications you need to avoid. You are also your doctor
or whether your medications belong to the above listed groups
inform them as you know.
If you are currently using any medicine with or without a prescription, or if you have been using it recently
please inform your doctor or pharmacist about these.
3. How to use LEPONEX?
Instructions for proper use and dose / application frequency:
Carefully follow your doctor's instructions. You do not exceed the recommended dose.
How many tablets does your doctor take exactly LEPONEX and how often do you use these tablets?
it will tell you what it needs.
Treatment-resistant schizophrenic patients:
Treatment usually begins once or twice a day with a 25 mg tablets half-day.
Your doctor will then gradually increase your dose until the ideal dose is achieved.
Your treatment will continue with a daily LEPONEX dose of 300 to 450 mg. Daily dose
usually, some of them in the morning some of the beds usually taken as divided parts. Some people may need doses up to 900 mg per day. Treatment of thoughts, emotions and behavior disorders in patients with Parkinson's disease: Treatment usually begins with a 25 mg tablets (12.5 mg) taken in the evening. Your doctor will then take your dose Your dose will continue with a daily dose of LEPONEX from 25 mg to 37.5 mg and will usually be taken as a single dose every evening.
Some people may need doses up to 50 mg / day. In exceptional cases,
your doctor may prescribe a higher dose, but the dose should never exceed 100 mg per day.
During the first weeks of treatment, your blood pressure will be measured.
You have to take LEPONEX every day at the same time,
Application path and method:
LEPONEX tablet is only used orally. LEPONEX tablet with food or on an empty stomach
You can take. Drink the tablet with a glass of water.
Different age groups:
Use in children:
The use of LEPONEX in children is not recommended.
Use in the elderly:
If you are 60 years of age or older, your doctor may need to adjust your treatment.
Special use cases:
Kidney / Liver failure:
LEPONEX tablets should be used with caution in patients with renal and hepatic insufficiency.
Unless your doctor recommends otherwise follow these instructions.
Your doctor will tell you how long your treatment will last with LEPONEX. Treatment is early
do not interrupt because stopping LEPONEX treatment causes your illness to get worse
If you have an impression that the effect of LEPONEX is too strong or weak
talk to your doctor or pharmacist.
If you use more LEPONEX than you need:
If you use LEPONEX, you must use a surplus with a doctor or pharmacist
If you accidentally use more tablets than you should, immediately call your doctor
Consult. You may need medical treatment.
If you forget to use LEPONEX
If you forget to take a dose, just take a dose. But if the next
If your dose has come in time or less than 4 hours in your next dose,
skip the forgotten tablets and take your next dose at the usual time.
If you have not taken LEPONEX for more than two days, do not start taking medication again
consult your doctor as soon as possible.
Do not take double doses to compensate for forgotten doses.
Possible effects of termination of treatment with LEPONEX
Do not abruptly stop using LEPONEX.
If this medicine should be discontinued for any reason, your doctor will
will gradually reduce the dose in 1 to 2 weeks. Buying LEPONEX suddenly or cutting dozen
rapid reduction can cause side effects.
For this reason, it is important that you and your carers manage the side effects of LEPONEX withdrawal
It is very important that you can recognize.
If LEPONEX is left unattended, the patient may experience psychotic symptoms and excessive sweating, headache
pain, nausea, vomiting and diarrhea may occur.
If you have any of the above, please tell your doctor immediately.
If you are not treated, this indication may be followed by more serious side effects.
4. What are the possible side effects?
As with all medicines, side effects in people sensitive to substances in the contents of LEPONEX
As a result of using LEPONEX, the following side effects may occur:
The side effects are listed as shown in the following categories:
Very common: it can be seen in at least 1 of 10 patients.
Common: less than one in 10 patients, but more than one in 100 patients.
Uncommon: less than one in 100 patients, but more than one in 1,000 patients.
Rare: less than one in 1,000 patients.
Very rare: less than one in 10,000 patients.
Fertility is not known: It can be seen in as few patients as can not be determined with the available data.
If any of the following occur, stop using LEPONEX and DERHAL
please contact your doctor or contact the emergency department of your nearest hospital:
• Continuing resting, possibly breathless and with feet or legs
a rapid and irregular heartbeat accompanied by a bump.
• Infection, such as fever, severe colds, sore throat or mouth ulcers.
LEPONEX reduces the number of white cells in your bloodstream and protects against infection
it can lead to increased sensitivity.
• Seizures (sara)
• Increase in the level of certain types of white blood cells, increase in the number of white blood cells
• Loss of consciousness, exhaustion
• Fever, muscle cramps, fluctuations in blood pressure, disorientation, dizziness
• Serious drop in blood pressure
• Chest pain due to cardiac inflammation
• Chest pain due to inflammation of the outer heart of the heart
• Blood clot
• Decrease in red blood cell level
• Food abstinence from the lungs
• If there is a statement of respiratory infections such as fever, coughing, respiratory distress, wheezing, and lung inflammation (pneumonia)
• Abdominal pain due to pancreatitis
• Yellow eye and skin, nausea, loss of appetite, dark urine as a sign of hepatic impairment, jaundice
• Spontaneous spontaneous bleeding and bruises (thrombocythemia) due to a low relative platelet level
• Kanda high platelet level
• Distorted orientation and blurring of consciousness, nausea / vomiting, excessive urination, high blood sugar and abdominal pain
• Chest pain, irregular heartbeats and heart failure
• Short and superficial breathing
• Feeling uncomfortable, vomiting with severe and prolonged constipation
• Yellow skin with abdominal pain and abdominal pain
• Kidney inflammation
• Erectile dysfunction
• Unexplained death
The fugitive is unknown:
• Venous thromboembolism (an event that leads to the formation of blood clots in the collecting vat)
• Liver disorders such as liver fatigue, liver cell death, liver toxicity / injury
• liver failure (which can lead to death), liver injury (liver cells, injuries to the bile duct or both through the liver) and liver transplant; cause loss of liver function; liver disorders in which normal liver tissue is replaced by scar tissue.
These are all very serious side effects.
You may need to be admitted to an emergency medical intervention or hospital.
Tell your doctor if you notice any of the following:
• Constipation (If your constipation worsens, tell your doctor.)
• Increased salivation
• Weight gain
• Speech disorders
• Abnormal movements, inability to initiate movement, inability to remain motionless, restlessness, hard limbs, tremor of hands
• Swing / Shake
• Muscle stiffness
• Blurred vision, reading difficulty
• Change in ECG
• dizziness while standing up due to blood pressure drop
• Increase in blood pressure
• Nausea, vomiting, mouth instability
• Elevation of liver enzymes
• Sweating and urination problems or urinary retention problems
• Stutter while talking
• Excessive thirst, dry mouth, and a high level of urination may be indicative of a high level of sugar (diabetes) on the hand. If you experience any of these, consult your doctor as soon as possible, as LEPONEX may cause diabetes or worsen diabetes.
• Irregular heartbeat
• Swallow difficulty
• Increase in muscle enzymes
• High cholesterol
• Kanda high fatty acids
• Purposeful movements such as facial crease, lip shuffle, quick blink
• Repeater and behaviors within an order (obsessive compulsive disorder)
• swelling of cheek cloths
• Skin reactions
The fugitive is unknown:
• Change to the machine that measures brain waves (EEG)
• Stomach anomalies, stomach upset, stomach upset after meals.
• Muscle weakness
• Muscle spasms
• Muscle aches
• Nasal obstruction
• Night work
These are minor side effects of LEPONEX.
If you encounter any side effects not mentioned in these instructions for use, please inform your doctor or pharmacist.
5. Storage of LEPONEX
Keep LEPONEX in a place where it can not be seen, can not be accessed by children and in its package.
Keep it at room temperature below 30ºC.
Use in accordance with expiration dates.
Do not use LEPONEX after the expiration date on the packaging.
Do not use LEPONEX unless you notice any defects in the product and / or packaging.
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