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New Leponex 25 Mg 50 Tablets ingredient Clozapine View larger

Leponex 25 Mg 50 Tablets ingredient Clozapine

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Leponex 25 Mg 50 Tablets ingredient Clozapine

LEPONEX® 25 mg tablet
It is taken orally.
• Active ingredient:
25 mg contains clozapine.

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You should read this USE INSTRUCTION carefully before you start using this medicine, because it contains important information for you.

• Keep these instructions for use. You can need to read again.
• If you have other questions, please talk your doctor or pharmacist.
• This medicine has been prescribed for you personally, do not give it to others.
• When using this medicine, tell your doctor or doctor if you go to the hospital.
• We sleep exactly as written in this instruction. Do not use high or low doses other than the recommended dose for the medication.

In this Instructions for Use:
1. What is LEPONEX and what is it used for?
2. Things to consider before using LEPONEX
3. How to use LEPONEX?
4. What are the possible side effects?
5. Storage of LEPONEX
Their headlines are in place.


1. What is LEPONEX and what is it used for?
LEPONEX tablets contain clozapine as active ingredient. LEPONEX is included in a drug group called antipsychotics.

LEPONEX has been used in the treatment of schizophrenia patients who have tried other antipsychotic drugs and have not benefited sufficiently from these drugs or who can not confer other antipsychotic drugs due to side effects.

LEPONEX is also used in the treatment of patients with schizophrenia or schizoaffective disorder (schizophrenia in which emotional disorders are observed), which otherwise might be an attempt to commit suicide.
Schizophrenia is a mental disorder in which thoughts, emotions and behavioral disorders are observed.
In addition, LEPONEX is also used in the treatment of thought, emotional and behavioral disorders in Parkinson's patients when the standard treatment fails. Parkinson's disease is a chronic (permanent) brain disease. This disease mainly affects how the brain coordinates the movements of the muscles in different parts of the body.
LEPONEX essentially acts by binding to and blocking the D4 receptor (or the dopamine receptor). LEPONEX also weakly binds and blocks the D1, D2, D3 and D5 receptors in the brain and other receptors that may contribute to its effectiveness.
LEPONEX can only be used with a doctor's prescription.

2. Things to consider before using LEPONEX

Before you start using LEPONEX, you will be given a blood test to determine if you can use this medicine. As long as you continue to use LEPONEX and after the cessation of treatment, you will have regular blood tests for 4 weeks. Your doctor will tell you when the tests will be done. It is important that you take all the blood tests that your doctor recommends.

LEPONEX may cause agranulocytosis. Its use should be limited to the following patient groups:
• In patients with schizophrenia who can not or do not respond to antipsychotic medication, psychosis in Parkinson's disease where other treatment strategies fail, or schizophrenia or schizoaffective disorder with recurrent suicidal behavior (see section 4.1)

(WHC ≥ 3500 / mm3 (3.5 x 109 / L) and absolute neutrophil count (ANC) ≥ 2000 / mm3 (2.0 x 109 / L)) at baseline in the normal white blood cell counts

• Treatment in patients with normal white blood cell count (WBC) and absolute neutrophil count (ANC) is as follows: During the first 18 weeks of treatment, once a week, then at least once every 4 weeks for blood testing. The patient should be monitored during LEPONEX treatment and during the first 4 weeks after treatment is discontinued.
Physicians should take the necessary precautions into consideration. Patients using LEPONEX should be reminded to contact the doctor immediately if any infection develops. Particular attention should be paid to flu-like complaints such as fever, sore throat and other infectious conditions such as neutropenia.
LEPONEX should be given under medical supervision in accordance with the official recommendation.

Myocarditis (inflammation of the heart)
Clozapine is associated with an increased risk of myocarditis resulting in death in some rare cases. The increased risk of myocarditis is highest in the first 2 months of treatment. Fatal cardiomyopathy (heart muscle disease) cases have also been reported rarely.
In particular, during the first 2 months of treatment, signs and symptoms of persistent tachycardia (acceleration of heart rate) and / or palpitations (arrhythmia), arrhythmia (heart rate irregularity), chest pain and other cardiac insufficiency (eg unexplained fatigue, dyspnea, myocarditis or cardiomyopathy should be suspected in patients who have symptoms that mimic myocardial infarction (heart attack), tachypnea (difficulty in breathing), tachycardia (very rapid breathing)
If myocarditis or cardiomyopathy is suspected, treatment with LEPONEX should be discontinued without delay and a cardiologist should be referred immediately.
Patients who develop clozapine-induced myocarditis or cardiomyopathy should not be re-exposed to clozapine.
Physicians who prescribe LEPONEX should fully comply with the warning.
Before treatment begins, physicians have to know whether the patient has had an undesirable hematological reaction that would require the cessation of treatment against clozapine. Prescriptions should not cover longer periods between two blood counts.

LEPONEX treatment must be stopped immediately if the number of white blood cells is less than 3000 / mm3 (3.0 x 109 / L) or the absolute number of neutrophils is less than 1500 / mm3 (1.5 x 109 / L) during LEPONEX treatment.
Patients who take LEPONEX should be reminded at every consent that they should contact the physician immediately in case of any infection. Particular attention should be paid to any infectious disease, such as fever or throat pain, which may be a sign of neutropenia. Patients and their relatives should be informed that an immediate blood count should be made when any of these symptoms occur. Prescribing physicians should keep all records of patients' blood counts.
DO NOT USE LEPONEX in the following situations
If:

• If you are allergic to clozapine or any of the ancillary substances listed at the beginning of this leaflet of LEPONEX,
• If you can not routinely test blood,
• If you have been diagnosed with a low white blood cell before, except after cancer treatment,
• If you have previously had bone marrow or have been living at the moment,
• If you use medications that prevent proper functioning of your bone marrow,
• If you use medications that reduce the number of white cells in your blood,

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