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• Active substance:
Each film contains 550 mg of naproxen sodium in the tablet.
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Use of APROL with food and drink
must be taken after APROL meals.
Consult your doctor or pharmacist before using the medicine.
Ita good evaluation of the benefits and the risks it will bring to the patient
requires. Therefore, the drug should not be used during pregnancy unless it is very necessary.
If you discover that you are pregnant during your treatment,doctor or pharmacist immediately
Consult your doctor or pharmacist before using the medicine.
Since naproxen sodium will pass into breast milk, it should not be given to breastfeeding mothers.
use ofand machinery
Some patients may experience dizziness, dizziness, insomnia orin combination with thetools
depression. If you and other undesirable effects occur,thatattention
be careful when performing activitiesrequire.
It is not recommended to useother drugs together with
APROL andpain, fever and inflammation.
If you take it with drugs that regulate stomach acid or cholestyramine, the effect of APROL
may be delayed.
Naproxen sodium binds to a protein called albumin. Yourcoumarin type
anticoagulant drugs, sulfonylureas, hydantoins, other pain, fever and inflammation (NSAID)
may interfere withdrugs, and other drug-binding drugs such as acetylsalicylic acid
doctor will adjust your APROL dose since. Naproxen sodium may, called platelets,
coagulate clottingby reducing the activity of cells involved in blood clotting
When used in combination with diuretic drugs such as furosemide, it can reduce the effect of these drugs.
When used in combination with lithium (used in mental disorders), lithium blood levels may
increase and side effects may occur.
When used in combination with warfarin (a drug that delays coagulation), thebleeding indigestive tract
When used in combination with cyclosporine and tacrolimus, an immunosuppressive drug, the
risk of kidney damage may increase.
When used in combination with mifepristone for the treatment of stomach and small intestine ulcers, it may
reduce the effect of mifepristone.
Whenthat increase pain, fever and inflammation of the heart, APROL
used in conjunction with glycosidesmay exacerbate heart failure andkidney
increase blood concentrations by affectingexcretion.
The pain, fever, and inflammation drugs inhuman immunodeficiency
which APROL is present canbloodwhen used in conjunction with the effective zidavudine to retroviruses, includingvirus (HIV)
increase the risk ofdiseases.
When combined with pain, fever and inflammation drugsby APROL andtreatment of depression, the
usedSSRIs used in therisk of gastrointestinal bleeding increases.
As with other pain, fever and inflammation drugs, when used with steroids, the
risk of digestive system ulcers and bleeding increases.
In animal studies, when pain, fever and inflammation-effective drugs and quinolone group antibiotics aretogether, the
usedsevere rhythmic contractions (convulsions)all or some of the voluntary muscles
risk ofmay increase in.
in combination with probenecid (a drug that increases uric acid excretion), as naproxen sodium
Caution should be exercisedmay have a higher effect in a shorter time.
Be careful when you use it with methotrexate (a drug used to treat cancer).
Naproxen sodium may reduce the excretion of methotrexate andside effects of methotrexate
8-12after using mifepristone becausewill reduce the effect of mifepristone
not use naproxen sodium fordaysnaproxen sodium.
It can reduce the effect of beta blockers used for high blood pressure treatment.naproxen sodium
Drugs that are effective in treatingand other pain, fever and inflammationdrugs used in the treatment of high blood pressure
can reduce the effect ofand increase the risk of kidney damage of ACE inhibitors.
As with other pain, fever and inflammatory drugstogether with contraceptives
, caution should be exercised due to the risk of ulcers and bleeding in the gastrointestinal tract when administered.
these expressionsalsoproducts that have been used for some time or that will be used for some time in the future
Please note thatmayapply to.
are currently using any prescription or non-prescription medication orhave recently
Please inform your doctor or pharmacist if youif youused it.
3. How to use APROL?
Instructions for proper use and dose / frequency of administration: The
recommended initial dose of APROL is two tablets (550 mg), followed by 2 tablets (550 mg) in 12 hourstablet
orevery 6-8 hours (275 mg). The starting daily total dose1375 mg (5
should not exceedtablets) and then 4 tablets (1100 mg).
Method and method:
of administrationTablets should be swallowed with a sufficient amount of liquid, for example a glass of water, without chewing.
Different age groups:
Use in children:
APROL is not recommended for children under 16 years of age. However, onlyjoint
10 mg / kg / day in children older than 5 years of age withinflammation should be used with an interval of 12 hours.
Use in the elderly: In the
elderly (65 years and older), the removal of the drug from the body mayreduced, the dose shouldcareful anddose should
bebethe lowest effectivebe used.
Kidney / Liver Failure: Do
Conditionsnot use APROL if your results are not suitable for your kidney function tests.
Be careful when using APROL if you have impaired liver function.
If you have an impression that the effect of APROL is too strong or weakdoctor
, talk to youror pharmacist.
If you use more APROL than you should use
Overdose headache, dizziness, heartburn, indigestion, nausea, vomiting,gastrointestinal
bleeding in thetract, sometimes diarrhea, drowsiness, dizziness, tinnitus, fainting
manifests itself. If a large number of tablets are taken accidentally or intentionally, stomach
should be emptied and known supportive measures should be taken.APROL
Activated charcoal should be applied 1 hour after receiving. Washing of the stomach in adultsalso
maybe considered. Frequent urination is recommended. Your doctoryour kidney and liver functions
will keepunder control.
Talk to a doctor or pharmacist if you have used APROL more than you should.
If you forget to use APROL
Do not take a double dose to compensate for the missed doses.
Effects that may occur when treatment with APROL is discontinued
4. What are the possible side effects?
Like all medicines, APROLhave side effects in people who are sensitive to the substances contained in its contents
If you have any of the following, stop using the APROL and IMMEDIATELYdoctor
tell youror contact your nearest hospital emergency department:
• Hands, feet, wrists, face, lips, mouth or throatswallow or breathe
swelling to make it difficult to
• Heart attack (chest pain) , stroke (weakness in muscles, loss of sensation, visual disturbances)
• Wheezing or difficult breathing (asthma attack)
• Skin rashes
• Skin, mouth, eyes, around the genitals; skin peeling, swelling, blisters and fever
with severe disease (Steven-Johnson syndrome)
• Mouth and other areas of the body of water in the form of collection or different sizes of
red rash with disease (erythema multiforme).
• A serious diseasecaused by skin peels and tissue loss with liquid-filled bubbles
(toxic epidermal necrolysis)
• Severe headache, neck stiffness, nausea, vomiting, and confusion (aseptic meningitis)
• Black color, such as blood or coffee grounds in stool and vomit (gastrointestinal bleeding)
These are all very serious side effects.
If you have one of these, you have a serious allergy to APROL.urgent medical
You may needattention or hospitalization.
All of these very serious side effects are very rare.
If you notice any of the following, report to your doctor immediately oryou
contact the emergency department of the hospital nearest:
• Anemia due to lack of some blood cells,of white
decrease in the numbercells in the blood, decrease in the number of platelets involved in blood clotting
• Increase in potassium in the blood
• Depression, sleep disorder, insomnia
• Transfer, coma, weakening of mental functions
• Inflammatory inflammation of the visual nerve
• Hearing impairment, tinnitus, dizziness
• High blood pressure, vascular occlusion
• Gastrointestinal disorders (indigestion, constipation, diarrhea, nausea, vomiting)
• sweating, hair loss, skin problems and skin rash, hives
• muscle pain and muscle weakness
• Women with infertility
• chills feeling, fever, malaise
• Deadly hepatitis, jaundice (loss of appetite, fatigue, liver Abnormalities infunction tests)
allThese are all serious side effects. Emergency medical intervention may be required.
Serious side effects are very rare.
If you notice any of the following, tell your doctor:
Dizziness, perturbation, headache, sensitivity to light,
• Shortness of breath
• Ulcer and damage in the stomach, vomiting, diarrhea, abdomen pain, burning in the stomach, constipation
• Itching, skin rash, staining on the skin, bruising
• Kidney disorders
• Edema, feeling of thirst
These are mild side effects of APROL.
If these symptoms do not occur spontaneously or are severe / distressing,doctor
Pleaseyou experience any side effects not mentioned in these instructions
inform your doctor or pharmacist if.
5. Storage of theAPROL in a placebe
APROL Store thewhere children cannot, cannot and cannotseen.
Store at room temperature below 30 ° C.
Use in accordance with the
expiry date Do not use APROL after the expiration date in the package.
Do not use APROL if you notice defects in the product and / or its packaging.
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